FLUPHENAZINE DECANOATE PACKAGE INSERT PDF

Rotate the site of injection to avoid irritation or sterile abscess formation with repeat administration. Intramuscular Depot injection (fluphenazine decanoate or . PACKAGE LEAFLET: INFORMATION FOR THE USER. Modecate® 25mg/ml Injection fluphenazine decanoate. Is this leaflet hard to see or read? Phone . ADMINISTRATION). Fluphenazine decanoate is not indicated for the management of severely agitated psychotic patients or psychoneurotic.

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If these drugs are administered together, obtain an electrocardiogram and electrolyte concentrations before and periodically during treatment. Parkinsonian-like states may occur particularly between the second and fifth days after each injection, but often decrease with subsequent injection. A dose reduction of one or both drugs may be warranted. Increases risk of photosensitivity.

Phenothiazines may prolong and intensify the sedative actions of CNS depressant medications e. Although the incidence of tardive dyskinesia from combination antipsychotic therapy has not been established and data are very limited, the risk appears to be increased during use of a conventional and atypical antipsychotic versus use fluphenazjne a conventional antipsychotic alone.

The in use shelf life for the 10ml vial is 28 days. Caution should be exercised during simultaneous use of these agents due to potential excessive CNS effects or additive hypotension. Fluphenazine depot injections must fluphenazien drawn up using a dry syringe and needle of at least gauge.

Phenothiazines may have deleterious effects on neuronal recovery following acute brain injuries. In all cases, the lowest possible dose and shortest duration should be prescribed. Caution should be exercised during simultaneous use of these agents due to potential for additive hypotension and decanowte CNS effects sedation and dizzinesswhich can impair the ability to undertake tasks requiring mental alertness.

Although QT interval prolongation has not been reported with gemtuzumab, it has been reported with other drugs that contain calicheamicin. Sudden, unexpected and unexplained deaths have been reported in hospitalised psychotic patients receiving phenothiazines.

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Phenothiazines may increase, prolong, or intensify the sedative action of other CNS depressants, such as alcohol. Minor Coadministration of ivosidenib with fluphenazine may increase the risk of QT prolongation.

Minor Bone marrow suppression is associated with guanidine therapy. There is an increased risk of stroke and greater rate of cognitive decline and mortality in persons with dementia receiving antipsychotics, and the Beers expert panel recommends avoiding antipsychotics to treat delirium- or dementia-related behavioral problems unless non-pharmacological options have failed or are not possible and the patient is a substantial threat to self or others.

To email a medicine you must sign up and log in. Decreases effectiveness ihsert increases toxicity of levodopa.

Rare occurrences of neuroleptic malignant syndrome NMS have been reported in patients on neuroleptic therapy. Phenothiazines should be discontinued 48 hours before the myelography and should not be resumed until at least 24 hours after the procedure. Patients should take care and use proper techniques to limit sunlight and UV exposure of treated areas. Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate: Furthermore, oxycodone is metabolized in part by 2D6 to oxymorphone, packate represents Ibutilide: Therefore, identify and address all possible causes dcanoate behavioral or psychological symptoms of dementia BPSD before considering an antipsychotic.

An interruption of therapy, dose reduction, or discontinuation of therapy may be necessary for crizotinib patients if QT prolongation occurs.

Moderate Additive effects may be seen when phenothiazines are used concomitantly with other drugs with antimuscarinic activity, fluphenazins as chlorpheniramine, a sedating H1-blocker. If drugs are withdrawn, recurrence of symptoms may not become apparent for several weeks or months.

Minor When used for the treatment of nausea and vomiting, antiemetic phenothiazines may effectively mask symptoms that are associated with ototoxicity induced by aminoglycosides.

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Cariprazine, like other antipsychotics, has the potential to impair judgment, thinking, or motor skills. Chronic antipsychotic treatment should generally be reserved for patients who suffer from a chronic illness that is known to respond to antipsychotics, and for whom alternative, equally effective, but potentially less harmful treatments are not available or appropriate. As with all antipsychotic agents, tardive dyskinesia may appear in some patients on long term therapy or may occur after drug therapy has been discontinued.

Psycholeptics; Phenothiazines with piperazine structure, ATC code: Reporting of suspected adverse reactions. Qualitative and quantitative composition 3.

Modecate Injection 25mg/ml

The risk for parkinsonism, NMS, or akathisia may be increased with packaeg administration. In Aprilthe FDA mandated that all manufacturers of atypical antipsychotics e. Theoretically, fluphenazine may increase the risk of QT prolongation if coadministered with drugs with a possible risk for QT prolongation.

Moderate Melatonin may exhibit pharmacodynamic interactions with the phenothiazines. Moderate Additive effects may be seen when phenothiazines are fluphnazine concomitantly with other drugs with antimuscarinic activity, such as meclizine, a sedating H1-blocker. If concurrent therapy is considered essential, ECG monitoring is recommended.

Modecate Injection 25mg/ml – Summary of Product Characteristics (SmPC) – (eMC)

Agents that inhibit intestinal motility or prolong intestinal transit time have been reported to induce toxic megacolon. According to the manufacturer, bepridil is contraindicated for use with drugs that prolong the QT interval due to the risk of TdP.

Fluconazole has been associated with QT prolongation and rare cases of TdP. Additive drowsiness or other additive CNS effects may also occur.